منابع مشابه
Incomplete Directed Perfect Phylogeny
Perfect phylogeny is one of the fundamental models for studying evolution. We investigate the following variant of the problem: The input is an n ×m species-characters matrix. The characters are binary and directed, i.e., a species can only gain characters. The difference from standard perfect phylogeny is that for some species the state of some characters is unknown. The question is whether on...
متن کاملThe Incomplete Perfect Phylogeny Haplotype Problem
The problem of resolving genotypes into haplotypes, under the perfect phylogeny model, has been under intensive study recently. All studies so far handled missing data entries in a heuristic manner. We prove that the perfect phylogeny haplotype problem is NP-complete when some of the data entries are missing, even when the phylogeny is rooted. We define a biologically motivated probabilistic mo...
متن کاملHaplotyping as Perfect Phylogeny
For diploid organisms (e.g. humans), each chromosome is present in two non-exact copies and the description of all the data from a single chromosome is called a haplotype. Obtaining haplotype data is important in applications such as analyzing complex diseases, however this is a very difficult problem to solve experimentally and finding mixed genotype data is much less technically difficult and...
متن کاملUnique perfect phylogeny is intractable
A phylogeny is a tree capturing evolution and ancestral relationships of a set of taxa (e.g., species). Reconstructing phylogenies from molecular data plays an important role in many areas of contemporary biological research. A phylogeny is perfect if (in rough terms) it correctly captures all input data. Determining if a perfect phylogeny exists was shown to be intractable in 1992 by Mike Stee...
متن کاملEfficient Enumeration of the Directed Binary Perfect Phylogenies from Incomplete Data
We study a character-based phylogeny reconstruction problem when an incomplete set of data is given. More specifically, we consider the situation under the directed perfect phylogeny assumption with binary characters in which for some species the states of some characters are missing. Our main object is to give an efficient algorithm to enumerate (or list) all perfect phylogenies that can be ob...
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ژورنال
عنوان ژورنال: SIAM Journal on Computing
سال: 2004
ISSN: 0097-5397,1095-7111
DOI: 10.1137/s0097539702406510